반응 #45821

반응 방정식

methanol

potassium hydroxide

methyl 4-bromo-2-tert-butyl-5-phenyl-1-benzofuran-7-carboxylate

→

compound

수율 95.0%

4-Bromo-2-tert-butyl-5-phenyl-1-benzofuran-7-carboxylic acid

수율 95.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The reaction liquid
2. 2
   농축was concentrated under reduced pressure
3. 3
   workup.ADDITION1 N hydrochloric acid (100 ml) and water (100 ml) were added
4. 4
   추출the product was extracted with ethyl acetate (200 ml×2)
5. 5
   세척The organic layer was washed with saturated brine (50 ml×2)
6. 6
   건조dried over anhydrous magnesium sulfate
7. 7
   농축concentrated under reduced pressure

실험 절차

A methanol (12 ml) solution of potassium hydroxide (1.26 g, 22.5 mol) was put into a tetrahydrofuran (50 ml) solution of methyl 4-bromo-2-tert-butyl-5-phenyl-1-benzofuran-7-carboxylate (I-255) (2.90 g, 7.49 mmol), followed by stirring at room temperature for 3.5 hours. The reaction liquid was concentrated under reduced pressure, then 1 N hydrochloric acid (100 ml) and water (100 ml) were added, the product was extracted with ethyl acetate (200 ml×2). The organic layer was washed with saturated brine (50 ml×2), then dried over anhydrous magnesium sulfate, concentrated under reduced pressure to obtain the entitled compound (2.64 g, 95%) as a yellow white solid.

출처