반응 #4579

반응 방정식

sodium hydroxide

α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide

water

→

title compound

3-isopropyl-3-methyl-7-n-propyl-3H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5-dione

용매

toluene

반응 조건

후처리

1. 1
   온도After the reaction solution has cooled
2. 2
   여과it is filtered through silica gel
3. 3
   세척the filtrate is washed with ethyl acetate
4. 4
   농축concentrated by evaporation
5. 5
   기타The residue is recrystallised from ethyl acetate/petroleum ether

실험 절차

With the simultaneous addition of 0.5 g of powdered sodium hydroxide, a solution of α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide (m.p.: 82° C.) in 100 ml of toluene is heated under reflux for 2 hours in a water separator. After the reaction solution has cooled, it is filtered through silica gel and the filtrate is washed with ethyl acetate and then concentrated by evaporation. The residue is recrystallised from ethyl acetate/petroleum ether, affording 13.1 g of the title compound which melts at 116° C.

출처