반응 #45777

반응 방정식

Nicotinyl chloride hydrochloride

triethylamine

dichloromethane

4-amino-6-fluoro-5-hydroxy-2-methylbiphenyl-3-carbonitrile

→

7-Fluoro-5-methyl-6-phenyl-2-(pyridin-3-yl)-1,3-benzoxazole-4-carbonitrile

용매

Ethyl acetate

반응 조건

후처리

1. 1
   세척by washing with water (50 ml) and saturated brine (50 ml)

실험 절차

Nicotinyl chloride hydrochloride (192 mg, 1.08 mmol) and triethylamine (301 μl, 2.16 mmol) were added to a dichloromethane (9 ml) solution of 4-amino-6-fluoro-5-hydroxy-2-methylbiphenyl-3-carbonitrile (I-41) (218 mg, 0.900 mmol), followed by stirring at room temperature for 2 hours. Ethyl acetate (100 ml) was added to the reaction liquid, followed by washing with water (50 ml) and saturated brine (50 ml).

출처