반응 #457070

반응 방정식

methyl 2,4-dihydroxybenzoate

methyl bromoacetate

potassium carbonate

→

ethyl 2-(3-hydroxy-4-methoxycarbonylphenoxy)acetate

용매

acetone

반응 조건

후처리

1. 1
   온도the mixture is refluxed for 3 hours
2. 2
   여과The mixture is filtered
3. 3
   농축the filtrate is concentrated
4. 4
   기타the residue is purified by silica gel column chromatography (solvent; n-hexane:ethyl acetate=3:1)

실험 절차

To a solution of methyl 2,4-dihydroxybenzoate (25.1 g) in acetone (250 ml) are added methyl bromoacetate (14.9 ml) and potassium carbonate (21.7 g), and the mixture is refluxed for 3 hours. The mixture is filtered, and the filtrate is concentrated, and the residue is purified by silica gel column chromatography (solvent; n-hexane:ethyl acetate=3:1) to give ethyl 2-(3-hydroxy-4-methoxycarbonylphenoxy)acetate (31.5 g).

출처