반응 #45639

반응 방정식

ethyl acetate

triethylamine

(3S)-3-(dimethylamino)pyrrolidine

7-Fluoro-2-(2-furyl)-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile

→

7-[(3S)-3-(Dimethylamino)pyrrolidin-1-yl]-2-(2-furyl)-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile

용매

brine

dimethyl sulfoxide

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   기타The aqueous layer was separated
3. 3
   추출this was extracted twice with ethyl acetate

실험 절차

7-Fluoro-2-(2-furyl)-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile (I-105) (40 mg, 0.13 mmol) was dissolved in anhydrous dimethyl sulfoxide (2 ml), and at room temperature, triethylamine (26 μl, 0.19 mmol) and (3S)-3-(dimethylamino)pyrrolidine (21 μl, 0.16 mmol) were added. This mixture liquid was stirred at 90° C. for 11 hours, then cooled to room temperature. This was fractionated with ethyl acetate and saturated brine. The aqueous layer was separated, and this was extracted twice with ethyl acetate.

출처