반응 #45607

반응 방정식

2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate

p-toluenesulfonic acid monohydrate

→

6-Bromo-2-cyclopropyl-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile

용매

toluene

반응 조건

후처리

1. 1
   온도under reflux for 19 hours

실험 절차

2-Amino-5-bromo-3-cyano-6-fluoro-4-methylphenyl acetate (I-76) (7.95 g, 25.38 mmol) was dissolved in toluene (80 ml), p-toluenesulfonic acid monohydrate (1.60 g, 20 wt. %) was added, followed by stirring under reflux for 19 hours.

출처