반응 #45579

반응 방정식

N-iodosuccinimide

acetic acid

4-bromo-3-fluoro-2-methoxy-5-methylaniline

→

4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

용매

brine

반응 조건

후처리

1. 1
   추출followed by extraction twice with ethyl acetate
2. 2
   세척the organic layer was washed three times with saturated brine
3. 3
   건조dried over anhydrous magnesium sulfate

실험 절차

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

출처