반응 #45552

반응 방정식

water

dichloromethane

N-(3-bromo-6-cyano-2-methoxy-5-methyl-4-styrylphenyl)-2,2-dimethylpropionamide

dichloromethane

tribromoborane

→

compound

수율 97.3%

N-(3-Bromo-6-cyano-2-hydroxy-5-methyl-4-styrylphenyl)-2,2-dimethylpropionamide

수율 97.3%

용매

brine

반응 조건

후처리

1. 1
   온도Afterwards, this was heated up to −12° C.
2. 2
   workup.STIRRINGstirred for 1 hour
3. 3
   기타The reaction liquid
4. 4
   workup.ADDITIONwas added
5. 5
   추출the intended product was extracted with ethyl acetate (50 ml×2)
6. 6
   건조The organic layer was dried over anhydrous magnesium sulfate
7. 7
   농축concentrated under reduced pressure

실험 절차

A dichloromethane (1.0 ml) solution of N-(3-bromo-6-cyano-2-methoxy-5-methyl-4-styrylphenyl)-2,2-dimethylpropionamide (I-11) (34 mg, 79.6 μmol) was cooled at −78° C., a dichloromethane solution of 1 N tribromoborane (239 μl, 239 μmol) was dropwise added, followed by stirring at −78° C. for 70 minutes. Afterwards, this was heated up to −12° C. and stirred for 1 hour. The reaction liquid was put into cold water (50 ml), saturated brine (50 ml) was added, the intended product was extracted with ethyl acetate (50 ml×2). The organic layer was dried over anhydrous magnesium sulfate, concentrated under reduced pressure to obtain the entitled compound (32 mg, 96%) as a yellow white semi-solid.

출처