반응 #4549

반응 방정식

(s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-4,6-dichloro-pyrimidine

magnesium oxide

ethanol

→

(s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-pyrimidine

용매

water

반응 조건

후처리

1. 1
   기타into a 200 ml flask, then add hydrogen under oil bath conditions at 50° C., until the logical amount of hydrogen has been absorbed
2. 2
   여과The catalyst is filtered
3. 3
   기타separated
4. 4
   추출ether is extracted
5. 5
   세척After the ether layer is washed with water and with saturated salt water
6. 6
   기타dried
7. 7
   기타the ether is evaporated

실험 절차

Pour 1.88 g of optically active (s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-4,6-dichloro-pyrimidine, 0.4 g of 10% palladium-carbon, 0.55 g of magnesium oxide, 60 ml of ethanol, and 45 ml of water, into a 200 ml flask, then add hydrogen under oil bath conditions at 50° C., until the logical amount of hydrogen has been absorbed. The catalyst is filtered and separated, then ether is extracted. After the ether layer is washed with water and with saturated salt water, and dried, the ether is evaporated. The resultant impure product is repeatedly refined, and 0.9 g of optically active (s)-5-n-octyl-2-[4-(6-methyloctyloxy)phenyl]-pyrimidine is obtained.

출처