반응 #45429

반응 방정식

solution

(4-amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol

→

desired product

수율 89.0%

4-amino-3-bromothieno[3,2-c]pyridine-7-carbaldehyde

수율 89.0%

용매

THF

반응 조건

후처리

1. 1
   여과filtered through diatomaceous earth (Celite®)
2. 2
   세척The pad was washed with THF and dichloromethane
3. 3
   농축the combined filtrates were concentrated

실험 절차

A solution of Example 277E (1 g, 3.86 mmol) in THF (100 mL) was treated with MnO2 (2.66 g, 42.1 mmol), stirred overnight at room temperature, and filtered through diatomaceous earth (Celite®). The pad was washed with THF and dichloromethane and the combined filtrates were concentrated to provide 0.88 g (89% yield) of the desired product. MS (ESI(+)) m/e 256.8, 258.8 (M+H)+.

출처