반응 #45428

반응 방정식

mixture

(3-bromo-4-chlorothieno[3,2-c]pyridin-7-yl)methyl acetate

NH4OH

→

desired product

수율 84.0%

(4-amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol

수율 84.0%

용매

dioxane

반응 조건

후처리

1. 1
   여과filtered
2. 2
   농축concentrated
3. 3
   기타to provide a soid which
4. 4
   기타was triturated with water (20 mL)
5. 5
   기타collected
6. 6
   기타dried

실험 절차

A mixture of Example 277D (3.1 g, 9.7 mmol), concentrated NH4OH (62 mL), and dioxane (62 mL) was heated to 150° C. in a sealed tube for 36 hours, filtered, and concentrated to provide a soid which was triturated with water (20 mL), collected and dried to give 2.1 g (84% yield) of the desired product. MS (ESI(+)) m/e 258.9, 260.8 (M+H)+.

출처