반응 #4539

반응 방정식

hydrazine hydrate

3-cyano-5-dimethoxymethyl-2-phthalimidopyrazine

→

2-amino-3-cyano-5-dimethoxymethylpyrazine

수율 75.1%

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONImmediately after the addition
2. 2
   기타crystals were precipitated after a few minutes

실험 절차

0.2 g of hydrazine hydrate were added dropwise to a suspension of 2 g of 3-cyano-5-dimethoxymethyl-2-phthalimidopyrazine in 40 ml of absolute methanol at 40° C. Immediately after the addition, the solution became clear, and crystals were precipitated after a few minutes. Chromatography over silica gel gave 0.9 g (75%) of 2-amino-3-cyano-5-dimethoxymethylpyrazine. 1H-NMR (270 MHz, DMSO-d6): δ3.3 (s, 6H), 5.0 (s, 1H), 8.35 (s, 1H).

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