반응 #453717

반응 방정식

Sodium hydride

3-azabicyclo[3.1.0]hexane-2,4dione

1-bromo-2-cyclohexylethane

→

title compound

3-[2-(Cyclohexyl)ethyl]-3-azabicyclo[3.1.0]hexane-2,4-dione

용매

dimethylformamide

water

반응 조건

후처리

1. 1
   추출extracted with toluene (20 ml)
2. 2
   추출The organic extract
3. 3
   세척was washed with water (15 ml)
4. 4
   건조dried (MgSO4)
5. 5
   기타evaporated in vacuo
6. 6
   workup.DISTILLATIONThe residue was purified by Kugelrohr distillation (boiling point 130-140° C. @ 0.1 mmHg)

실험 절차

Sodium hydride (0.11 g) was added to a solution of 3-azabicyclo[3.1.0]hexane-2,4dione (0.3 g) and 1-bromo-2-cyclohexylethane (0.52 g) in dimethylformamide (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 16 hours. The mixture was diluted with water (15 ml) and then extracted with toluene (20 ml). The organic extract was washed with water (15 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by Kugelrohr distillation (boiling point 130-140° C. @ 0.1 mmHg) to give the title compound as a colourless oil.

출처