반응 #45313

반응 방정식

2-bromo-5-fluoro benzyl bromide

3,5-bis(trifluoromethyl)benzylamine

triethyl amine

→

title compound

[3,5-Bis(trifluoromethyl)benzyl](2-bromo-5-fluorobenzyl)amine

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure

실험 절차

To a solution of 2-bromo-5-fluoro benzyl bromide (0.5 g, 1.86 mmol) and 3,5-bis(trifluoromethyl)benzylamine (0.45 g, 1.86 mmol) in methylene chloride (10 ml) at 0° C., triethyl amine (0.39 ml, 2.80 mmol) was added. The solution was slowly warmed to room temperature and stirred for 18 h. The solvent was removed under reduced pressure. The title compound was obtained by flash column chromatography using EtOAc/hexane (2:8) as the eluant. 1H NMR (CDCl3, 500 MHz) δ 7.88 (s, 2H), 7.80 (s, 1H), 7.53 (dd, J=8.8, 5.3 Hz, 1H), 7.18 (dd, J=9, 3.3 Hz, 1H), 6.91 (dt, J=8.5, 3.3 Hz, 1H), 3.98 (s, 2H), 3.90 (s, 2H).

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