반응 #45299

반응 방정식

potassium carbonate

5-(2-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole

→

2-(2-chlorophenyl)bicyclopropyl

수율 89.8%

용매

ethylene glycol

반응 조건

후처리

1. 1
   기타prepared
2. 2
   기타the upper, product phase is separated off

실험 절차

To a solution of 50 g (0.36 mol) of potassium carbonate in 600 g of ethylene glycol there are added at 190° C., in the course of 2 hours, 201.5 g of 5-(2-chlorophenyl)-3-cyclopropyl-4,5-dihydro-1H-pyrazole, prepared as described under A2. Stirring is then carried out for 2 hours at 190° C. The end of the reaction is indicated by cessation of the evolution of gas. The reaction mixture is then cooled to 100° C., whereupon phase separation occurs and the upper, product phase is separated off. 158 g of 2-(2-chlorophenyl)bicyclopropyl are obtained as crude product, which may be further purified, for example by distillation.

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