반응 #452974

ord-7a44d432676a486e85928259a153decd

반응 방정식

COC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
racemic tryptophan methyl ester
O=Cc1ccccc1Cl
2-chlorobenzaldehyde
→
COC(=O)C1Cc2c([nH]c3ccccc23)C(c2ccccc2Cl)N1
title compound
COC(=O)C1Cc2c([nH]c3ccccc23)C(c2ccccc2Cl)N1
Methyl 1,2,3,4-tetrahydro-1-(2-chlorophenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

반응물

COC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
racemic tryptophan methyl ester
O=Cc1ccccc1Cl
2-chlorobenzaldehyde

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The same method but starting from racemic tryptophan methyl ester and 2-chlorobenzaldehyde gave the title compound as white crystals m.p.: 154° C.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06127542uspto-grants-2000_10