반응 #45288

반응 방정식

8-(2,2,2-Trifluoroethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

HCl

→

1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride

용매

acetone

반응 조건

후처리

1. 1
   온도After refluxing for 12 h
2. 2
   기타the solvent was removed

실험 절차

8-(2,2,2-Trifluoroethyl)-1,4-dioxa-8-aza-spiro[4.5]decane (3.7 g, 16 mmol) was added to a solution of 5% HCl (45 mL) and acetone (8 mL). After refluxing for 12 h, the solvent was removed to give crude 1-(2,2,2-trifluoroethyl)piperidin-4-one hydrochloride which was used in the next reaction.

출처