반응 #45286

반응 방정식

benzophenone imine

aminoacetonitrile hydrochloride

→

(benzhydrylideneamino)acetonitrile

수율 157.5%

용매

dichloromethane

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   기타to remove the precipitated ammonium chloride
3. 3
   기타the filtrate was evaporated to dryness in vacuo
4. 4
   workup.DISSOLUTIONThe resulting residue was dissolved in ether (400 mL)
5. 5
   세척washed with water (200 mL) and brine
6. 6
   건조After drying over magnesium sulfate the solution
7. 7
   기타was evaporated

실험 절차

A mixture of benzophenone imine (25 g, 0.138 mol, Aldrich) and aminoacetonitrile hydrochloride (25 g, 0.270 mol, Lancaster) in dichloromethane (1000 mL) was stirred in a 2 L Erlenmeyer flask under nitrogen at room temperature for 5 days. The reaction mixture was filtered to remove the precipitated ammonium chloride and the filtrate was evaporated to dryness in vacuo. The resulting residue was dissolved in ether (400 mL) washed with water (200 mL) and brine. After drying over magnesium sulfate the solution was evaporated to give (benzhydrylideneamino)acetonitrile (47.89 g).

출처