반응 #452427

반응 방정식

ethyl isocyanate

3-(1-pyrrolidinyl)propylamine

→

urea

수율 96.4%

N-ethyl-N'-3-(1-pyrrolidinyl)propylurea

수율 96.4%

용매

chloroform

반응 조건

후처리

1. 1
   온도with cooling
2. 2
   workup.ADDITIONOnce the addition
3. 3
   기타the cooling bath was removed
4. 4
   농축The reaction mixture was then concentrated under reduced pressure

실험 절차

To a solution of 27.7 gm (0.39 mole) ethyl isocyanate in 250 mL chloroform were added 50 gm (0.39 mole) 3-(1-pyrrolidinyl)propylamine dropwise with cooling. Once the addition was complete, the cooling bath was removed and the reaction mixture stirred at room temperature for 4 hours. The reaction mixture was then concentrated under reduced pressure to give 74.5 gm (96.4%) of the desired urea as a clear oil.

출처