반응 #452426

반응 방정식

2-iodopropane

2-(4-pyrazolyl)-1-ethanol

sodium carbonate

→

title compound

수율 26.0%

2-(1-isopropyl-1H-pyrazol-4-yl)-1-ethanol

수율 26.0%

용매

dimethylformamide

dimethylformamide

반응 조건

후처리

1. 1
   온도The reaction mixture was then cooled to ambient and
2. 2
   농축then concentrated under reduced pressure
3. 3
   기타The residue was partitioned between water and dichloromethane
4. 4
   세척The organic phase was then washed with water
5. 5
   건조was then dried over sodium sulfate
6. 6
   농축The remaining organics were concentrated under reduced pressure

실험 절차

To a solution of 1.0 gm (9.0 mMol) 2-(4-pyrazolyl)-1-ethanol in 36 mL dimethylformamide were added 2.38 gm (22.5 mMol) sodium carbonate followed by the dropwise addition of a solution of 0.89 mL (9.0 mMol) 2-iodopropane in 8 mL dimethylformamide. The reaction mixture was heated to 100° C. for 18 hours. The reaction mixture was then cooled to ambient and then concentrated under reduced pressure. The residue was partitioned between water and dichloromethane. The organic phase was then washed with water followed by saturated aqueous sodium chloride and was then dried over sodium sulfate. The remaining organics were concentrated under reduced pressure to give 0.36 gm (26.0%) of the title compound as a brown oil.

출처