반응 #452423

반응 방정식

water

4-fluorobenzoyl chloride

4-nitroaniline

pyridine

→

N-(4-fluorobenzoyl)-4-nitroaniline

수율 91.3%

용매

dichloromethane

반응 조건

후처리

1. 1
   workup.WAITfor an hour at room temperature
2. 2
   기타the solid which formed
3. 3
   여과was collected by filtration
4. 4
   세척The filter cake was washed with hexane (80 mL)
5. 5
   기타was then dried under vacuum at 60° C.

실험 절차

To a stirred suspension of 19.83 gm (143.56 mMol) 4-nitroaniline in 150 mL dichloromethane and 12.9 mL (159.5 mMol) pyridine at 0° C. were slowly added 24.5 gm (154.8 mMol) 4-fluorobenzoyl chloride. The reaction mixture was then stirred for 15 minutes at 0° C., at which time the reaction mixture became homogeneous, and then for an hour at room temperature. To this mixture were then added 100 mL water and the solid which formed was collected by filtration. The filter cake was washed with hexane (80 mL) followed by water (100 mL) and it was then dried under vacuum at 60° C. to give 34.1 gm (91%) N-(4-fluorobenzoyl)-4-nitroaniline.

출처