반응 #451249

반응 방정식

Thionyl chloride

3,4-dimethoxy-phenylacetic acid

→

3,4-Dimethoxy-phenylacetic acid chloride

용매

methylene chloride

반응 조건

후처리

1. 1
   기타(16 hours)
2. 2
   온도is refluxed for a further hour
3. 3
   기타After the highly volatile components have been removed the residue
4. 4
   workup.DISTILLATIONis distilled in vacuo

실험 절차

Thionyl chloride (600 ml) is added dropwise, with stirring, over a period of 2 hours, to a suspension of 3,4-dimethoxy-phenylacetic acid (549.4 g) in methylene chloride (600 ml). After the development of gas has ended (16 hours) the mixture is refluxed for a further hour. After the highly volatile components have been removed the residue is distilled in vacuo.

출처