반응 #45100

반응 방정식

5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine

ethyl 4-(4-cyclobutylpiperazin-1-yl)benzoate

trimethylaluminium

acetone

→

title compound

수율 23.3%

4-(4-Cyclobutylpiperazin-1-yl)-N-[5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-yl]benzamide

수율 23.3%

용매

Acetonitrile

toluene

toluene

반응 조건

후처리

1. 1
   기타4-(4-Cyclobutylpiperazin-1-yl)-N-[5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-yl]benzamide was prepared
2. 2
   기타quenched with excess damp sodium sulphite
3. 3
   여과filtered
4. 4
   기타evaporated
5. 5
   기타to afford a yellow solid
6. 6
   여과this was filtered

실험 절차

4-(4-Cyclobutylpiperazin-1-yl)-N-[5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-yl]benzamide was prepared following the procedure as outlined for Example 100, starting from 5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine (0.173 g, 0.69 mmol), ethyl 4-(4-cyclobutylpiperazin-1-yl)benzoate (0.2 g, 0.69 mmol) and a 2M solution of trimethylaluminium in toluene (1.387 mL, 2.77 mmol) in toluene (10 ml) at room temperature for 20 h. The reaction mixture was poured into acetone (20 mL), quenched with excess damp sodium sulphite, filtered and evaporated to afford a yellow solid. Acetonitrile (10 ml) was added and this was filtered to afford the title compound (0.079 g, 23.17%) as a white solid.

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