반응 #45078

반응 방정식

carbonate

5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine hydrochloride

→

5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine

수율 67.5%

용매

methanol

water

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   세척MP carbonate was washed with 10% MeOH in DCM
3. 3
   기타This was evaporated to dryness

실험 절차

MP carbonate (2.74 mmol/g) (12.00 g, 32.88 mmol) was added to 5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine hydrochloride (5 g, 17.50 mmol) in methanol (200 mL) and water (20 mL). The resulting suspension was stirred at room temperature for 18 h. The reaction mixture was filtered and MP carbonate was washed with 10% MeOH in DCM. This was evaporated to dryness to afford 5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine (2.94 g, 67.5%) as an orange waxy solid.

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