반응 #450537

반응 방정식

acetyl 6-O-acetyl-2,3-di-O-benzoyl-4-chloro-4-deoxy-D-galactopyranoside

hydrazine acetate

→

6-O-acetyl-2,3-di-O-benzoyl-4-chloro-4-deoxy-D-galactopyranose

수율 95.3%

용매

DMF

반응 조건

후처리

1. 1
   기타The reaction mixture was then evaporated
2. 2
   세척washed with water (5 times)
3. 3
   기타evaporated
4. 4
   기타The residue was chromatographed on a silica gel
5. 5
   세척eluting with hexane-ethyl acetate (2:1)

실험 절차

A solution of acetyl 6-O-acetyl-2,3-di-O-benzoyl-4-chloro-4-deoxy-D-galactopyranoside (68) (8.53 g, 17.4 mmol) and hydrazine acetate (2.4 g, 26.0 mmol, 1.5 eq) in 70 mL of DMF was stirred for 1 hour at room temperature. The reaction mixture was then evaporated, washed with water (5 times) and evaporated. The residue was chromatographed on a silica gel, eluting with hexane-ethyl acetate (2:1), to provide 6-O-acetyl-2,3-di-O-benzoyl-4-chloro-4-deoxy-D-galactopyranose (7.44 g, 95.3%). This material was dissolved in dichloromethane (50 mL) and the resulting solution was cooled to 0° C. Trichloroacetonitrile (8.3 mL, 82.9 mmol) was added and the mixture was stirred for 2 hours. The solvent was then evaporated and the residue was chromatographed on a silica gel column, eluting with hexane-ethyl acetate (3:1), to give imidate 69 (6.3 g, 64%).

출처