반응 #450199

반응 방정식

triphenylphosphine dibromide

6-5

4-(1,3-diphenyl-1-propoxy)benzyl alcohol

pyridine

→

product 6-6

4-(1,3-diphenyl-1-propoxy)benzyl bromide

용매

acetonitrile

반응 조건

후처리

1. 1
   여과at ambient temperature for 1 &3/4 hrs and then was filtered
2. 2
   기타Concentration of the filtrate in vacuo gave a crude oil

실험 절차

To an ice cold solution of 6-5 (1.19 g, 6.0 mmol) in acetonitrile (15 ml) was added pyridine (0.76 g, 9.6 mmol) and then triphenylphosphine dibromide (3.29 g, 7.8 mmol). The mixture was stirred at ice bath temperature for 1/4 hr under N2 and at ambient temperature for 1 &3/4 hrs and then was filtered. Concentration of the filtrate in vacuo gave a crude oil. The pure product 6-6 was obtained after three silica gel chromatographic separations.

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