반응 #449986
ord-9fffec0f198b4e048795124dd3fd9a26
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The mixture was filtered through Celite (diatomaceous earth)
- 2농축the filtrate was concentrated in vacuo
실험 절차
A mixture of 4-fluorocinnamic acid (300.0 g, 1.8 mol, Aldrich) and 5% palladium on carbon (9.0 g) in ethanol (3 L) was hydrogenated at atmospheric pressure and room temperature for 4.5 h. The mixture was filtered through Celite (diatomaceous earth) and the filtrate was concentrated in vacuo to give 275.1 g (91%) of 3-(4-fluorophenyl)propionic acid as a white solid: m.p., 86°-88° C.;