반응 #44997

반응 방정식

Monomethyl adipate

morpholine

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

triethylamine

→

methyl 6-morpholin-4-yl-6-oxohexanoate

수율 100.4%

용매

chloroform

반응 조건

후처리

1. 1
   온도cooling
2. 2
   추출the mixture is extracted with chloroform
3. 3
   세척The organic layer is washed with 10% hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine successively
4. 4
   건조dried over sodium sulfate
5. 5
   기타The solvent is removed by evaporation under reduced pressure

실험 절차

Monomethyl adipate (3.20 g) is dissolved in chloroform (70 ml), and thereto are added morpholine (2.61 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (5.75 g) and triethylamine (3.04 g) under ice-cooling. The mixture is then stirred at room temperature for 19 hours. Ice-water is added to the reaction solution and the mixture is extracted with chloroform. The organic layer is washed with 10% hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine successively and dried over sodium sulfate. The solvent is removed by evaporation under reduced pressure to give methyl 6-morpholin-4-yl-6-oxohexanoate (4.63 g).

출처