반응 #44994

반응 방정식

Methyl trans-4-(morpholin-4-ylcarbonyl)cyclohexane-carboxylate

sodium hydroxide

→

title compound

수율 78.5%

Trans-4-(morpholin-4-ylcarbonyl)cyclohexane-carboxylic acid

수율 78.5%

용매

methanol

반응 조건

후처리

1. 1
   농축The reaction solution is concentrated under reduced pressure
2. 2
   workup.ADDITIONThe residue is diluted with ice-water
3. 3
   추출extracted with chloroform
4. 4
   건조The organic layer is dried over sodium sulfate
5. 5
   농축the solvent is concentrated under reduced pressure

실험 절차

Methyl trans-4-(morpholin-4-ylcarbonyl)cyclohexane-carboxylate (860 mg) obtained in Reference Example 82(1) is dissolved in methanol (40 ml), and thereto is added 4 N aqueous sodium hydroxide solution (1.68 ml). The mixture is then stirred at room temperature for 18 hours. The reaction solution is concentrated under reduced pressure. The residue is diluted with ice-water, neutralized with 10% hydrochloric acid and extracted with chloroform. The organic layer is dried over sodium sulfate and the solvent is concentrated under reduced pressure to give title compound (638 mg).

출처