반응 #44954

반응 방정식

Pseudomonic acid

potassium hydroxide

calcium chloride

→

Mupirocin Calcium

용매

ethanol

반응 조건

후처리

1. 1
   여과the solution was filtered
2. 2
   기타to remove potassium chloride (0.51 g)
3. 3
   기타The ethanol was subsequently evaporated at reduced pressure
4. 4
   기타to give a solid, white foam
5. 5
   기타The product was dried for 12 hours at 45° C. under vacuum

실험 절차

Pseudomonic acid (5.00 g, 10 mmole) was dissolved in ethanol (20 ml), ethanolic solution of potassium hydroxide (0.56 g, 10 mmole potassium hydroxide and 10 ml ethanol) and ethanolic solution of calcium chloride (0.56 g, 5.0 mmole calcium chloride and 10 ml ethanol) were added to the mixture. The mixture was stirred for 1 hour and the solution was filtered to remove potassium chloride (0.51 g). The ethanol was subsequently evaporated at reduced pressure to give a solid, white foam. The product was dried for 12 hours at 45° C. under vacuum. The product had a mass of 4.38 grams. Assay: 99.1%, water: 2.36% [total impurity: 2.44%, highest impurity: 1.10% different method than the assay].

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