반응 #449401

반응 방정식

2-fluoro-3-iodopyridine

trimethylsilylacetylene

→

2-fluoro-3-(trimethylsilylethynyl)pyridine

수율 94.6%

용매

THF

triethylamine

반응 조건

후처리

1. 1
   기타The solvents were evaporated
2. 2
   기타The organic phase was separated
3. 3
   기타dried
4. 4
   기타evaporated
5. 5
   workup.DISTILLATIONDistillation of the residue

실험 절차

A mixture of 2-fluoro-3-iodopyridine (5 g), trimethylsilylacetylene (2.86 g) copper(I) iodide (0.015 g) and bis(triphenylphosphine)palladium dichloride (0.06 g) in a mixture of THF (20 mL) and triethylamine (30 mL) was stirred under argon for 4 hours. The solvents were evaporated and the residue was taken up in water/ethyl acetate. The organic phase was separated, dried and evaporated. Distillation of the residue gave 2-fluoro-3-(trimethylsilylethynyl)pyridine as an oil (4.10 g).

출처