반응 #448742

반응 방정식

D-tryptophan

sulfuric acid

ethanol

octanal

→

(3R)-1,2,3,4-Tetrahydro-1-heptyl-β-carboline-3-carboxylic Acid

용매

methanol

반응 조건

후처리

1. 1
   농축The solution is concentrated
2. 2
   기타The methanol is evaporated at 45° C.
3. 3
   여과the precipitate is filtered off
4. 4
   세척washed with water
5. 5
   기타dried
6. 6
   기타The solid obtained
7. 7
   온도After cooling
8. 8
   기타the compound of preparation F
9. 9
   기타crystallizes
10. 10
    여과It is then filtered
11. 11
    기타dried

실험 절차

A mixture containing 147 mmol of D-tryptophan, 294 ml of 1 N sulfuric acid, 300 ml of ethanol and 294 mmol of octanal is stirred at 45° C. for 72 hours. The solution is concentrated and the residue is taken up in a water/methanol/ammonium hydroxide mixture. The methanol is evaporated at 45° C. and the precipitate is filtered off, washed with water and dried. The solid obtained is solubilized at high temperature in methanol. After cooling, the compound of preparation F crystallizes. It is then filtered and dried.

출처