반응 #44854

반응 방정식

tert-butyl 4-cyanotetrahydro-2H-pyran-4-carboxylate

→

title compound

수율 83.0%

tert-butyl 4-(aminomethyl)tetrahydro-2H-pyran-4-carboxylate

수율 83.0%

용매

methanol

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   기타for 12 h
3. 3
   여과Then, the mixture was filtered through a pad of Celite
4. 4
   농축the filtrate was concentrated in vacuo

실험 절차

A mixture of tert-butyl 4-cyanotetrahydro-2H-pyran-4-carboxylate (18.95 g, 0.0897 mol, step 1) and Raney Ni (1.00 g) in methanol (200 mL) was hydrogenated (3 atm) at room temperature for 12 h. Then, the mixture was filtered through a pad of Celite, and the filtrate was concentrated in vacuo to give 16.01 g (83%) of the title compound as a yellow syrup.

출처