반응 #44776

반응 방정식

4-(chlorocarbonyl)phenyl acetate

triethylamine

2,2-dimethoxyethanamine

→

4-(2,2-dimethoxyethylcarbamoyl)phenyl acetate

수율 81.1%

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with ethyl acetate
3. 3
   여과filtered
4. 4
   세척The filtrate was washed with water
5. 5
   추출The aqueous layer was extracted with ethyl acetate (2×)
6. 6
   세척The combined organic layers were washed with water, dilute mono-potassium phosphate (pH=5.4
7. 7
   건조pH of solution about 7), water, and brine, dried
8. 8
   농축concentrated

실험 절차

A solution of 4-(chlorocarbonyl)phenyl acetate (110 g, 553.87 mmol) in CH2Cl2 (500 mL) was cooled in an ice bath and treated with triethylamine (115 mL, 830 mmol, 1.5 equiv.) and 2,2-dimethoxyethanamine (63.36 mL, 581.56 mmol, 1.05 equiv.). The reaction mixture was allowed to warm to ambient temperature and the reaction was followed by TLC (CH2Cl2). The reaction mixture was concentrated under reduced pressure, diluted with ethyl acetate and filtered. The filtrate was washed with water. The aqueous layer was extracted with ethyl acetate (2×). The combined organic layers were washed with water, dilute mono-potassium phosphate (pH=5.4, pH of solution about 7), water, and brine, dried, and concentrated to give 120 g (81% th.; 109% pract.) of 4-(2,2-dimethoxyethylcarbamoyl)phenyl acetate as a light brown waxy solid with no further purification; 1H NMR (CDCl3) δ 7.79 (d, 2H), 7.15 (d, 2H), 6.32 (br. t, 1H), 4.47 (t, 1H), 3.58 (d, 2H), 3.41 (s, 6H), 2.30 (s, 3H) ppm.

출처