반응 #44747

ord-c8bb75df87cd4049a4db105c0cecc52b

반응 방정식

CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2
1,1-dimethylethyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
COC(=O)c1ccc(CBr)cc1OC
methyl 2-methoxy-4-(bromomethyl)benzoate
→
COC(=O)c1ccc(CN2C[C@@H]3C[C@H]2CN3)cc1OC
methyl 2-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate

반응물

CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2
1,1-dimethylethyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
COC(=O)c1ccc(CBr)cc1OC
methyl 2-methoxy-4-(bromomethyl)benzoate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In like manner, 1,1-dimethylethyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate and methyl 2-methoxy-4-(bromomethyl)benzoate are reacted together to give methyl 2-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07737145B2uspto-grants-2010_06