반응 #44743

반응 방정식

N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-piperidin-3-ylpyrimidine-2,4-diamine

N4-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-piperidin-3-ylpyrimidine-2,4-diamine

2-bromopropane

potassium carbonate

→

N4-[3-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-(1-isopropylpiperidin-3-yl)pyrimidine-2,4-diamine

용매

DMF

반응 조건

후처리

1. 1
   여과The suspension is filtered off with suction
2. 2
   기타the filtrate is purified by preparative HPLC

실험 절차

50 mg (0.119 mmol) of N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-piperidin-3-ylpyrimidine-2,4-diamine (from example 134) are dissolved in DMF. 0.013 ml (0.143 mmol) of 2-bromopropane and 49 mg (0.358 mmol) of potassium carbonate are added, and the mixture is stirred at room temperature for 18 hours. The suspension is filtered off with suction and the filtrate is purified by preparative HPLC.

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