반응 #44712

반응 방정식

4-(4-amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine

4-(4-Amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine

2-amino-4,6-dichloropyrimidine

hydrochloric acid

→

N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-(2-amino-6-chloro-4-pyrimidinyl)amine

용매

water

반응 조건

후처리

1. 1
   온도The reaction mixture is heated
2. 2
   온도at reflux overnight
3. 3
   기타resulting in the formation of a colorless precipitate
4. 4
   여과This is filtered off
5. 5
   세척washed repeatedly with water
6. 6
   기타dried under high vacuum

실험 절차

100 mg (0.39 mmol) of 4-(4-amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine (from example VII) and 63.3 mg (0.39 mmol) of 2-amino-4,6-dichloropyrimidine are suspended in 3 ml of water, and 0.04 ml of concentrated hydrochloric acid is added. The reaction mixture is heated at reflux overnight, resulting in the formation of a colorless precipitate. This is filtered off, washed repeatedly with water and dried under high vacuum.

출처