반응 #4471

반응 방정식

product

6-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one

potassium carbonate

dimethylsulphate

→

title compound

수율 97.5%

6-Fluoro-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one

수율 97.5%

용매

acetone

반응 조건

후처리

1. 1
   농축The mixture was concentrated to one half of its volume
2. 2
   여과The mixture was filtered off
3. 3
   세척washed with water (50 ml)
4. 4
   기타air-dried for 1 h
5. 5
   건조dried in vacuo over phosphorus pentoxide

실험 절차

The product of Stage (ii) (7.28 g), potassium carbonate (9.90 g), acetone (70 ml), and dimethylsulphate (5.1 ml) were vigorously stirred at room temperature overnight under nitrogen. The mixture was concentrated to one half of its volume and then stirred with water (350 ml) for 30 min. The mixture was filtered off, washed with water (50 ml), air-dried for 1 h, and dried in vacuo over phosphorus pentoxide to give the title compound as needles (7.59 g), m.p. 157.5°-158.5°.

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