반응 #44636

반응 방정식

Trifluoroacetic acid

methylene chloride

[(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester

sodium hydrogencarbonate

→

title compound

수율 91.1%

(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propylamine

수율 91.1%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타The resulting reaction solution
2. 2
   기타The organic layer was separated
3. 3
   세척washed with a saturated sodium hydrogencarbonate aqueous solution and with saturated saline in this order
4. 4
   농축concentrated under reduced pressure

실험 절차

Trifluoroacetic acid (0.5 mL) was added to a methylene chloride solution (2 mL) of [(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester (370 mg). The resulting reaction solution was stirred at room temperature for 11 hr, and a saturated sodium hydrogencarbonate aqueous solution and ethyl acetate were added thereto. The organic layer was separated, washed with a saturated sodium hydrogencarbonate aqueous solution and with saturated saline in this order, and concentrated under reduced pressure to give 275 mg of the title compound. The physical property values of this compound were as follows:

출처