반응 #4462

반응 방정식

N-[[(4-methoxycarbonylphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine

sodium hydroxide

→

N-[[(4-carboxyphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine

수율 56.6%

용매

methanol

chloroform

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타After evaporation of the solvent
3. 3
   추출the residue was extracted with chloroform (20 ml×3)
4. 4
   세척The extract was washed with water
5. 5
   건조dried over magnesium sulfate
6. 6
   농축concentrated in vacuo
7. 7
   기타The residue was purified by column chromatography on silica gel (40 g)
8. 8
   세척eluting with chloroform

실험 절차

To a solution of N-[[(4-methoxycarbonylphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine (1.21 g) in a mixture of methanol (30 ml) and chloroform (30 ml) was added. 1N sodium hydroxide (10 ml) and the mixture was stirred at ambient temperature for 18 hours. After evaporation of the solvent, the residue was extracted with chloroform (20 ml×3). The extract was washed with water, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel (40 g) eluting with chloroform, to give N-[[(4-carboxyphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine (0.65 g).

출처