반응 #446140

반응 방정식

Na2CO3

5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole

triethylamine

→

title compound

5-Cyclopropyl-3-isocyanomethyl-1,2,4-oxadiazole

용매

H2O

CH2Cl2

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타was separated
3. 3
   기타dried
4. 4
   기타evaporated in vacuo
5. 5
   workup.ADDITIONThe residue was treated with ether
6. 6
   기타decanted
7. 7
   기타the solution was evaporated

실험 절차

A stirred solution of 5-cyclopropyl-3-formylamino-methyl-1,2,4-oxadiazole (60 mmol) and triethylamine (176 mmol) in CH2Cl2 (100 ml) was charged dropwise with POCL3 (60 mmol) at 0° C. The mixture was then left for 30 minutes with stirring at 0° C., whereafter a solution of Na2CO3 (60 mmol) in H2O (50 ml) was added. The mixture was heated to room temperature, whereafter the organic phase was separated, dried and evaporated in vacuo. The residue was treated with ether, decanted and the solution was evaporated to give the title compound as an oil. The oil was processed without any further purification. The compound was characterized by its IR absorbtion band at 2160 cm-1.

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