반응 #4461

반응 방정식

water

N-[[(4-fluorophenyl)carbamoyl]-imino]pyridinium

sodium borohydride

sodium borohydride

→

N-[[(4-fluorophenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine

용매

ethanol

반응 조건

후처리

1. 1
   기타the resulting mixture was evaporated
2. 2
   추출The residue was extracted with chloroform (20 ml×3)
3. 3
   추출The combined organic extract
4. 4
   세척was washed with water
5. 5
   건조dried over magnesium sulfate
6. 6
   기타evaporated
7. 7
   기타to give crystalls
8. 8
   기타Recrystallization from diisopropyl ether

실험 절차

A suspension of N-[[(4-fluorophenyl)carbamoyl]-imino]pyridinium ylide (1.04 g) and sodium borohydride (2.55 g) in ethanol (100 ml) was stirred at ambient temperature for 16 hours. Excess of sodium borohydride was decomposed with water, and the resulting mixture was evaporated. The residue was extracted with chloroform (20 ml×3). The combined organic extract was washed with water, dried over magnesium sulfate and evaporated to give crystalls. Recrystallization from diisopropyl ether gave N-[[(4-fluorophenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine (0.60 g).

출처