반응 #445811

반응 방정식

5-bromopentanol

dihydropyran

→

title compound

수율 52.0%

5-Bromopentyltetrahydropyranylether

수율 52.0%

반응 조건

후처리

1. 1
   세척Chromatography on alumina eluted with petroleum ether

실험 절차

Three drops of phosphoryl chloride were added to a stirred mixture of 5-bromopentanol (34.3 g, 205 mmol) and dihydropyran (19.0 g, 226 mmol). After standing for one hour, the mixture was fractionated. Yield 34.7 g, b.p. 102° C. (0.2 bar). Chromatography on alumina eluted with petroleum ether gave the pure title compound (25.1 g, 52% of theory) as an oil.

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