반응 #445620
ord-7067370980904d529ab71b7ad55b6b99
반응 방정식
3-[(4-chlorophenyl)thio]-azacycloheptan-2-one
methyl isocyanate
dibutyl-tin dilaurate
→
1-(methylcarbamoyl)-3-[(4-chlorophenyl)thio]-azacycloheptan-2-one
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도under reflux for 5 hours
- 2온도After the mixture has cooled
실험 절차
25.6 g (0.1 mol) of 3-[(4-chlorophenyl)thio]-azacycloheptan-2-one together with 5.7 g (0.1 mol) of methyl isocyanate and 100 mg of dibutyl-tin dilaurate in 150 ml of absolute toluene are boiled under reflux for 5 hours. After the mixture has cooled, the solvent is stripped off in vacuo, and the oily residue is used for further reactions.