반응 #44554

반응 방정식

2,6-dichloropyrazine

2-fluorophenol

AcOEt

→

title compound

수율 80.0%

2-Chloro-6-(2-fluorophenyl-oxy)-pyrazine

수율 80.0%

용매

cyclohexane

반응 조건

실험 절차

Using Method DD with 2,6-dichloropyrazine (250 mg, 1.69 mmol) and 2-fluorophenol (166 μL, 1.86 mmol, d=1.26 g/mL), and purification by column chromatography (AcOEt:cyclohexane, 1:1), the title compound was obtained (302 mg). Yield: 80%. 1H NMR (250 MHz, DMSO-d8) δ 7.31-7.45 (m, 4H, Harom), 8.56 (s, 1H, HPz 5), 8.67 (s, 1H, HPz 3).

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