반응 #445287

반응 방정식

Dioxolane

tetraethylammonium fluoride dihydrate

acetic acid

tetrahydrofuran

→

3-(4-Methyl-2-oxo-1,3-dioxolan-4-yl)-4-(2-oxopropyl)-2-azetidinone

용매

ethyl acetate

반응 조건

후처리

1. 1
   세척washed with saturated saline
2. 2
   기타dried
3. 3
   농축concentrated
4. 4
   기타The residue purified by silica gel chromatography
5. 5
   기타to give
6. 6
   세척eluted with benzene-ethyl acetate (1:5)

실험 절차

A mixture of Dioxolane (B-5)(1.62 g), tetraethylammonium fluoride dihydrate (1.38 g) and acetic acid (0.5 ml) in tetrahydrofuran (10 ml) is stirred at room temperature for 2 hours. The reaction mixture is diluted with ethyl acetate (50 ml), washed with saturated saline, dried and concentrated. The residue purified by silica gel chromatography to give tilted Lactam (C-5)(895 mg) from the fractions eluted with benzene-ethyl acetate (1:5).

출처