반응 #4452

반응 방정식

2-benzyl-4-(2-chloro-4-pyridyl)thiazole

→

2-benzyl-4-[2-(1-piperidyl)-4-pyridyl]thiazole dihydrochloride

수율 73.5%

용매

piperidine

반응 조건

후처리

1. 1
   온도to reflux for 16 hours
2. 2
   농축The reaction mixture was concentrated
3. 3
   여과filtered through celite
4. 4
   세척the filtrate washed with water (2×)
5. 5
   건조The ether layer was dried
6. 6
   농축concentrated
7. 7
   workup.ADDITIONtreated with an excess of dry hydrochloric acid

실험 절차

A solution of 2-benzyl-4-(2-chloro-4-pyridyl)thiazole (1.00 g, 0.0035 mol) in piperidine (15 mL) was heated to reflux for 16 hours. The reaction mixture was concentrated, taken up in ether (50 mL), filtered through celite, and the filtrate washed with water (2×). The ether layer was dried and concentrated. The residue was taken up in ethanol (20 mL) and treated with an excess of dry hydrochloric acid. Careful dilution with ether afforded 2-benzyl-4-[2-(1-piperidyl)-4-pyridyl]thiazole dihydrochloride (525 mg, 49%). mp. 145° C.

출처