반응 #44505

반응 방정식

solution

tert-butyl-(cyclohept-4-enyloxy)-diphenyl-silane

ethyl diazoacetate

→

title compound

4-(tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   기타The solvent was evaporated in vacuo and product
2. 2
   기타purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20)

실험 절차

To a solution of Example 8C (2.2 g, 6.28 mmoles) and Rh2(OAc)4 (2 mg, 4.3 μmol) in dichloromethane (2 mL), ethyl diazoacetate (0.717 g, 6.28 mmoles) in dichloromethane (4 mL) was added over two hours via a syringe pump. The solvent was evaporated in vacuo and product purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20) to provide the title compound.

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