반응 #44501

반응 방정식

LiOH

product

9-[4-(5-Cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester

methanol

water

→

9-[4-(5-Cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-bicyclo[3.3.1]nonane-3-carboxylic acid

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타by partitioning with diethyl ether and water
2. 2
   세척The organic layer was washed with water
3. 3
   추출extracted with ethyl acetate
4. 4
   건조The combined ethyl acetate phases were dried (MgSO4)
5. 5
   여과filtered
6. 6
   기타evaporated
7. 7
   기타The acid product was used without further purification

실험 절차

LiOH (0.2 g, 4.84 mmol) was added in one portion to a stirred solution of the product of Example 7E (0.532 g, 1.21 mmol) in a mixture of tetrahydrofuran (6 mL), methanol (3 mL), and water (3 mL). The resulting solution was stirred overnight, followed by partitioning with diethyl ether and water. The organic layer was washed with water and the combined water layers were acidified with NaHSO4 solution and extracted with ethyl acetate. The combined ethyl acetate phases were dried (MgSO4), filtered, and evaporated. The acid product was used without further purification.

출처