반응 #44497

반응 방정식

3-Bromo-2-bromomethyl-propionic acid methyl ester

1-cyclohex-1-enyl-pyrrolidine

triethyl amine

acetic acid

→

title compound

9-Oxo-bicyclo[3.3.1]nonane-3-carboxylic acid methyl ester

용매

CH3CN

water

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.ADDITIONwere added
3. 3
   온도Then, heating
4. 4
   기타The solvent was evaporated
5. 5
   기타the residue was partitioned with diethyl ether and water
6. 6
   세척The organic phase was washed with a NaHCO3 solution until the washes
7. 7
   기타It was then dried
8. 8
   여과filtered
9. 9
   기타evaporated
10. 10
    기타The residue was purified over silica gel using 2-30% diethyl ether in hexanes

실험 절차

3-Bromo-2-bromomethyl-propionic acid methyl ester (30 g, 115 mmol) was added to a stirred solution of freshly distilled 1-cyclohex-1-enyl-pyrrolidine (20.4 mL, 126 mmol) and triethyl amine (35 mL, 252 mmol) in dry CH3CN (400 mL). After the addition, the mixture was heated (100° C.) and stirred for twelve hours before acetic acid (20 mL) and water (100 mL) were added. Then, heating was continued for another three hours. The solvent was evaporated and the residue was partitioned with diethyl ether and water. The organic phase was washed with a NaHCO3 solution until the washes became basic. It was then dried, filtered, and evaporated. The residue was purified over silica gel using 2-30% diethyl ether in hexanes to give the title compound as a clear oil.

출처